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Use "Imigran" as directed by your doctor. This medication should be taken twice daily, with the doses 7 hours apart. The first dose should preferably be taken in the morning upon waking up, unless directed otherwise by your doctor. Do not suddenly stop taking Imigran . You may have an increased risk of side effects (e.g., angina attacks). If you need to stop ISMO or add a new medicine, your doctor will gradually lower your dose.